Table 1.
COS parameters and results
| Robertsonian translocation | Reciprocal translocation | |
|---|---|---|
| Couples | 51 | 131 |
| Female carriers | 16 | 67 |
| Male carriers | 35 | 64 |
| COS cycle | 55 | 181 |
| Patients with one stimulation cycle | 48 | 86 |
| Patients with ≥ 2 stimulation cycles | 3 | 45 |
| Average maternal age (years) | 31.2 ± 3.7 | 30.7 ± 3.9 |
| Maternal BMI (kg/m2) | 20.8 ± 3.0 | 21.2 ± 4.1 |
| Basal FSH (IU/L) | 5.7 ± 1.8 | 5.7 ± 1.7 |
| Basal E2 (pg/ml) | 34.4 ± 15.8 | 36.0 ± 16.1 |
| Initial dose of Gn (IU) | 196.2 ± 61.4 | 198.9 ± 56.6 |
| Stimulation length (days) | 11.2 ± 1.7 | 11.2 ± 2.0 |
| Total amount of Gn (IU) | 2337.3 ± 913.8 | 2396.7 ± 878.4 |
| HCG day E2 (pg/ml) | 3207 ± 1429.5 | 2891 ± 1403.8 |
| Retrieved oocytes/OPU | 19.8 ± 8.7* | 17.0 ± 8.2* |
| MII | 16.4 ± 7.1* | 14.0 ± 6.6* |
| 2PN (fertilized) | 12.6 ± 5.7 | 11.6 ± 5.6 |
| Cleavage rate/% | 94.8 ± 8.3 | 96.5 ± 10.2 |
| Mean number of embryos biopsied | 7.4 ± 3.6 | 8.0 ± 3.5 |
| Number of normal/balanced embryos | 3.1 ± 2.2* | 2.1 ± 1.6* |
| Couples without Normal/balanced embryos for FET | 4 | 16 |
Data are expressed as mean ± SD. Data refer to analyzed cycles that were only those who were completed; cancelled cycles are not included in the analysis
COH controlled ovarian hyperstimulation, Gn gonadotropins, OPU oocyte pick-up, MII metaphase II, FET frozen embryo transfer
*P <0.05; significant difference between Robertsonian translocation group and reciprocal translocation group ( Welch t test with F test for variance performed as appropriate)