Table 2.
Outcomes of biopsied blastocysts
| Population biopsy results |
Robertsonian Translocation |
Reciprocal Translocation |
Maternal age ≥37 years |
Maternal age <37 years |
|---|---|---|---|---|
| Biopsied embryos | 379 | 1053 | 85 | 1347 |
| Embryos diagnosed | 355(93.7) | 986(93.6) | 77(90.6) | 1264(93.8) |
| Normal/balanced translocation without aneuploidy | 160(45.1)a | 283(28.7)a | 17(22.1)b | 426(33.7)b |
| Balanced, with other aneuploidy | 105(29.6)a | 182(18.5)a | 23(29.9)b | 258 (20.4)b |
| Unbalanced, without other aneuploidy | 72(20.3)a | 425(43.1)a | 25(32.5)b | 473(37.4)b |
| Unbalanced, with other aneuploidy | 18(5.1)a | 96(9.7)a | 12(15.6)b | 107(8.5)b |
| Embryos undiagnosed | 24(6.3) | 67(6.4) | 8(9.4) | 83(6.2) |
| Total abnormality | 195(51.4) | 703(66.8) | 60(70.6) | 838(62.2) |
| Mean diagnostic rate of normal/balanced translocation %c | 40.7 ± 21.8(34.6–46.9) | 27.3 ± 19.8(23.9–30.7) | – | – |
Values are expressed as n (%) or mean ± standard deviation of the mean (95 % confidence interval)
aSignificant differences (P < 0.05) within translocation type (chi-square test): Pearson = 79.63, P < 0.001
bSignificant differences (P < 0.05) within maternal age (chi-square test): Pearson = 10.69, P = 0.014
cStudent’s t test: t = 3.99, P < 0.001