Table 1.
Summary of epidemiological and clinical characteristics of septic shock patients who underwent major surgery
| Characteristics | All patients | IL-6 rs1800795 polymorphism | ||
|---|---|---|---|---|
| GG/CG | CC | p value* | ||
| No. of patients | 202 | 183 | 19 | – |
| Gender (male) | 128 (63.4%) | 115 (62.8%) | 13 (68.4%) | 0.631 |
| Age (years) | 73 (17) | 73 (17) | 73 (17) | 0.974 |
| Prior or pre-existing conditions | ||||
| Smoker | 36 (17.8%) | 35 (19.1%) | 1 (5.3%) | 0.207 |
| Alcoholism | 15 (7.4%) | 14 (7.7%) | 1 (5.3%) | 0.999 |
| Obesity | 30 (14.9%) | 27 (14.8%) | 3 (15.8%) | 0.999 |
| Diabetes | 26 (12.9%) | 23 (12.6%) | 3 (15.8%) | 0.718 |
| Heart disease | 95 (45.5%) | 82 (44.8%) | 10 (52.6%) | 0.515 |
| Chronic obstructive pulmonary disease | 35 (17.3%) | 28 (15.3%) | 7 (36.8%) | 0.027 |
| Hypertension | 111 (50.0%) | 100 (54.6%) | 11 (57.9%) | 0.789 |
| Chronic kidney disease | 30 (14.9%) | 28 (15.3%) | 2 (10.5%) | 0.745 |
| Cancer | 47 (23.3%) | 41 (22.4%) | 6 (31.6%) | 0.395 |
| Liver disease | 9 (4.5%) | 8 (4.4%) | 1 (5.3%) | 0.597 |
| Surgery | ||||
| Cardiac (vs. abdominal) | 81 (40.1%) | 75 (41%) | 6 (31.6%) | 0.426 |
| Emergency (vs. scheduled) | 128 (63.4%) | 116 (63.4%) | 12 (63.2%) | 0.984 |
| Severity indexes | ||||
| SOFA score | 9 (4) | 9 (4) | 9 (3) | 0.932 |
| APACHE-II score | 16 (5) | 17 (5) | 15 (8) | 0.758 |
| Infection | ||||
| Gram-positive | 99 (49%) | 92 (50.3%) | 7 (36.8%) | 0.265 |
| Gram-negative | 106 (52.5%) | 100 (54.6%) | 6 (31.6%) | 0.055 |
| Fungus | 39 (19.3%) | 35 (19.1%) | 4 (21.1%) | 0.767 |
| Catheter bacteraemia | 68 (33.7%) | 63 (34.4%) | 5 (26.3%) | 0.476 |
| Surgical site infection | 48 (23.8%) | 45 (24.6%) | 3 (15.8%) | 0.573 |
| Urinary tract infection | 24 (11.9%) | 21 (11.5%) | 3 (15.8%) | 0.479 |
| Endocarditis | 10 (5%) | 8 (4.4%) | 2 (10.5%) | 0.239 |
| Peritonitis | 95 (47%) | 86 (47%) | 9 (47.4%) | 0.975 |
| Pneumonia | 95 (47%) | 89 (48.6%) | 6 (31.6%) | 0.156 |
Values are expressed as median (interquartile range) and absolute count (%)
Note that patients may have had more than one organism cultured
SOFA Sequential Organ Failure Assessment, APACHE Acute Physiology and Chronic Health Evaluation
* p values were calculated by Chi-squared test or Fisher’s exact test for categorical variables and Mann–Whitney test for continuous variables. Statistically significant differences are shown in italics