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. 2017 Mar 1;8:276. doi: 10.3389/fmicb.2017.00276

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Copyright © 2017 Martínez, Oliveros, Cuesta, de la Barrera, Ausina, Casals, de Lorenzo, García, García-Fojeda, Garmendia, González-Nicolau, Lacoma, Menéndez, Moranta, Nieto, Ortín, Pérez-González, Prat, Ramos-Sevillano, Regueiro, Rodriguez-Frandsen, Solís, Yuste, Bengoechea and Melero.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Apoptosis pathway. This pathway is a simplified version of the Apoptosis pathway from the Kyoto Encyclopedia of Genes and Genomes (KEGG), shown in Supplementary Figure S1. Only those parts of the KEGG pathway that are relevant for this study are shown in the Figure. Host cell genes commonly up-regulated by K. pneumoniae, S. pneumoniae, S. aureus and RSV are highlighted in red and yellow border (FC ≥ 2, FDR ≤ 0.1), red (FC ≥ 2, no FDR), or brown (FC ≥ 1.5, no FDR), depending on the statistical parameters being considered. This color-code is also used in Supplementary Figures S1–S4 and in Figures 3–5.