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. 2017 Mar 1;8:86. doi: 10.3389/fphys.2017.00086

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Copyright © 2017 Ji, Park, Lee, Park, Son and Hong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dex-induced inhibition of LPS-induced inflammatory cytokine expression and cAMP concentration. (A) SMG cells were stimulated with LPS, treated with 100 ng/ml Dex, and then IL-6 mRNA and protein expression were measured in cell lysates (Lys) and cell supernatants (Sup). (B) Bars represent the mean ± SEM (n = 4, #p < 0.05). (C) LPS-induced Nox2 and Nox4 mRNA expression in the presence of 100 ng/ml Dex. (D) Analysis of Nox2 and Nox4 mRNA expression in the presence of the indicated components (n = 5, ^*p < 0.01). (E) PDE4 protein expression in LPS-stimulated SMG cells. The arrowheads indicate PDE4A and PDE4D bands at 65 and 102 kDa, respectively. (F) Analysis of PDE4 expression. Bars show the mean ± SEM (n = 4). (G) cAMP ratios in Dex-treated whole SMG cells (n = 4, ^*p < 0.01).