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. 2017 Mar 1;8:86. doi: 10.3389/fphys.2017.00086

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Copyright © 2017 Ji, Park, Lee, Park, Son and Hong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic model of Dex-modulated signaling. Dex, dexmedetomidine; α2_A-AR, α2_A-adrenoceptor; NKCC1, Na⁺-K⁺-2Cl⁻ cotransporter1; AE2, anion exchanger2; SLC26A6, solute carrier 26 family A6; Nox4, NADPH oxidase 4; LPS, lipopolysaccharide; TLR4, toll-like receptor 4; PDE, phosphodiesterase; YOH, yohimbine. Acute (black) and long-lasting (red) treatment with Dex.