Figure 4.

Matrix metalloproteinase-1 (MMP-1) (A), MMP-2 (B), MMP-9 (C), and TIMP-1 (D) expression into the mice lung bronchoalveolar lavage fluid, intratracheally instilled with double (bleomycin twice) dose of bleomycin and compared with vehicle (saline) treated control mice groups. MMP-1, MMP-2, MMP-9, and TIMP-1 expression was detected at 7, 14, and 21 days posttreatment. Nine animals were used for each time point, and each time point was repeated three times. The data represent the mean ± SEM of a total of 27 animals. Changes were compared to the vehicle groups using ANOVA followed by Dunnett’s test. *p < 0.05; **p < 0.01.