Skip to main content
. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Eur J Endocrinol. 2015 Dec 1;174(5):R225–R238. doi: 10.1530/EJE-15-0916

Figure 4.

Figure 4

Alternative splicing signature in human islets exposed to pro-inflammatory cytokines. Heat maps representing the expression of differentially expressed mRNA isoforms (DEIs) in human islet samples exposed to: (A) control (ctrl) vs cytokines (cyt; IL1β+IFNγ); (B) control (ctrl) vs the free fatty acid palmitate (pal); and (C) cytokines vs palmitate. DEIs were obtained from analysis of previous RNA-seq datasets generated by our group (11, 113) (unpublished data), filtered according to their log2 fold change ratio (only DEIs with values higher than four are represented) and hierarchically clustered using GenePattern modules (reads per kilobase of transcript per million values log transformed, not centred and not normal normalised). Green colour indicates low expressed isoforms while red colour indicates high expressed isoforms.