Table I.
Newly formed total and hard callus at the osteotomy site at days 14 and 42 (presented as mean and standard error of the mean)
| Callus volume (mm3) |
Mineral content (mg) |
Bone density (mg/cm3) |
||||
|---|---|---|---|---|---|---|
| Group | Day 14 | Day 42 | Day 14 | Day 42 | Day 14 | Day 42 |
| Newly formed total callus (> 299 mg/cm3) | ||||||
| Control | 44.0 (4.5) | 64.0 (9.0) | 19.7 (2.4) | 33.0 (5.1) | 445.8 (11.6) | 512.2 (8.1) |
| Tadalafil | 44.9 (5.8) | 66.3 (10.1) | 20.8 (3.2) | 34.1 (5.7) | 458.4 (14.6) | 510.0 (8.5) |
| COMB-4 | 37.3 (3.9) | 63.2 (4.8) | 16.4 (1.9) | 31.7 (2.8) | 438.4 (4.5) | 500.0 (8.9) |
| Newly formed hard callus (> 500 mg/cm3) | ||||||
| Control | 15.1 (2.2) | 35.7 (5.5) | 10.0 (1.4) | 24.6 (3.6) | 659 (4.7) | 693.2 (11.9) |
| Tadalafil | 16.4 (2.4) | 35.6 (5.6) | 11.0 (1.6) | 24.1 (3.7) | 665 (1.0) | 697.2 (5.5) |
| COMB-4 | 13.3 (1.4) | 33.4 (3.5) | 8.8 (0.9) | 22.8 (2.4) | 661 (4.4) | 683.7 (2.5) |
n = 4 for day 14 control and tadalafil, and day 42 COMB-4 groups; n = 5 for day 14 COMB-4 and day 42 control and tadalafil groups
COMB-4: L-citrulline, Paullinia cupana, ginger and muira puama