Table 2.

Spatial sorting factors and chaperones involved in spatial PQC

	JUNQ/INQ	IPOD	Regulates inclusion formation	References
Hsp104	x	x	+++	16 17 42 43 44 45 47
Ssa1/2	x	x	+++	42 46 57
Sse1	nd	nd	+++	42
Ydj1	nd	nd	+++	42 45
Sti1	nd	nd	+ (JUNQ/INQ)	16 43
Sis1	x	x	++ (JUNQ/INQ)	57 72
Hsp42		x	+++ (IPOD)	17 42 43 57 72
Hsp82	nd	nd	++	42
Mca1	x	x	−	45 72
Btn2	x	x	+++ (JUNQ/INQ)	43 57 72
Cur1	x		+	57
Vac17	nd	nd	++	63
Hsp26	x	x	−	17 42
Tsa1	x	x	−	38
Ltn1		x	+++ (IPOD)	69

Localization of studied sorting factors and chaperones to quality control sites and the dependence on their presence for proper inclusion formation. Major determinants of spatial sorting denoted with +++, less important factors ++, and factors displaying only a minor role in sorting are denoted with +. Chaperones and aggregate‐associated factors that do not affect spatial sorting are denoted with −. nd, localization in respect to quality control sites has not been determined.