Table 2.
Association of IL1RA and IL4 VNTRs genotype and allele distribution with demographic and anthropometric classes.
| Genotypes/alleles | Gender | Ethnicity | BMI class | WC class | TBF class | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Male | Female | Malay | Chinese | Indian | Nonobese | Obese | Normal | High | Normal | High | |
| IL1RA | |||||||||||
| I/I | 124 (96.9) | 177 (94.7) | 23 (100) | 245 (97.6) | 33 (80.5) | 250 (95.8) | 51 (94.4) | 241 (96.0) | 60 (93.8) | 218 (98.6) | 83 (88.3) |
| I/II | 4 (3.1) | 9 (4.8) | 0 | 5 (2.0) | 8 (19.5) | 10 (3.8) | 3 (5.6) | 9 (3.6) | 4 (6.2) | 2 (0.9) | 11 (11.7) |
| II/II | 0 | 1 (0.5) | 0 | 1 (0.4) | 0 | 1 (0.4) | 0 | 1 (0.4) | 0 | 1 (0.5) | 0 |
| χ2; p | NP | ||||||||||
| I | 252 (98.4) | 363 (97.1) | 46 (100) | 495 (98.6) | 74 (90.2) | 510 (97.7) | 105 (97.2) | 491 (97.8) | 124 (96.9) | 438 (99.1) | 177 (94.1) |
| II | 4 (1.6) | 11 (2.9) | 0 | 7 (1.4) | 8 (9.8) | 12 (2.3) | 3 (2.8) | 11 (2.2) | 4 (3.1) | 4 (0.9) | 11 (5.9) |
| p | 0.30 | M versus C: 1.00; M versus I: 0.05; C versus I: <0.001∗ | 0.73 | 0.52 | 0.001∗ | ||||||
| IL4 | |||||||||||
| B1/B1 | 84 (65.6) | 108 (57.8) | 10 (43.5) | 167 (66.5) | 15 (36.6) | 160 (61.3) | 32 (59.3) | 153 (61.0) | 39 (60.9) | 141 (63.8) | 51 (54.3) |
| B1/B2 | 31 (24.2) | 57 (30.5) | 11 (47.8) | 67 (26.7) | 10 (24.4) | 74 (28.4) | 14 (25.9) | 69 (27.5) | 19 (29.7) | 60 (27.1) | 28 (29.8) |
| B2/B2 | 13 (10.2) | 22 (11.8) | 2 (8.7) | 17 (6.8) | 16 (39.0) | 27 (10.3) | 8 914.8) | 29 (11.6) | 6 (9.4) | 20 (9.0) | 15 (16.0) |
| χ2; p | 2.02; 0.37 | NP | 0.93; 0.63 | 0.31; 0.86 | 3.98; 0.14 | ||||||
| B1 | 199 (77.7) | 273 (73.0) | 31 (67.4) | 401 (79.9) | 40 (48.8) | 394 (75.5) | 78 (72.2) | 375 (74.7) | 97 (75.8) | 342 (77.4) | 130 (69.1) |
| B2 | 57 (22.3) | 101 (27.0) | 15 (32.6) | 101 (20.1) | 42 (51.2) | 128 (24.5) | 30 (27.8) | 127 (25.3) | 31 (24.2) | 100 (22.6) | 58 (30.9) |
| χ2; p | 1.82; 0.18 | 37.78; <0.001∗ | 0.51; 0.48 | 0.06; 0.80 | 4.75; 0.03∗ | ||||||
Parentheses indicate percentage within the same demographic/anthropometric class; NP = χ2 test not performed due presence of cell having the count of less than 5; p values by χ2 or Fisher's exact test; ∗p value significant at <0.05; p values for ethnicity are combination analysis of Malay versus Chinese, Malay versus Indian, and Chinese versus Indian.