Table 3.
Top 30 differentially expressed genes: MSC-17 versus MSC-γ.
| Gene symbol | Gene name | mRNA Accession | Fold change | p value |
|---|---|---|---|---|
| Upregulated genes | ||||
| MMP13 | Matrix metallopeptidase 13 (collagenase 3) | NM_002427 | 24.27 | 0.0009 |
| HIST1H2AI | Histone cluster 1, H2ai | NM_003509 | 17.44 | 0.0005 |
| U3 | Small nucleolar RNA U3 | ENST00000390893 | 13.96 | 0.0118 |
| ZNF25 | Zinc finger protein 25 | ENSG00000175395 | 13.66 | 0.0008 |
| LRRC15 | Leucine rich repeat containing 15 | NM_001135057 | 13.57 | 0.0005 |
| HIST1H3G | Histone cluster 1, H3g | NM_003534 | 12.68 | 0.0008 |
| SNORD114-11 | Small nucleolar RNA, C/D box 114-11 | NR_003204 | 12.33 | 0.0386 |
| HIST1H3B | Histone cluster 1, H3b | NM_003537 | 11.20 | 0.0064 |
| U1 | U1 spliceosomal RNA | NONHSAT054977 | 10.54 | 0.0017 |
| HIST1H1B | Histone cluster 1, H1b | NM_005322 | 10.28 | 0.0003 |
| SCD | Stearoyl-CoA desaturase (delta-9-desaturase) | NM_005063 | 10.15 | 0.0008 |
| KRT16P4 | Keratin 16 pseudogene 4 | ENST00000453883 | 9.11 | 0.0122 |
| ADAM12 | ADAM metallopeptidase domain 12 | NM_001288973 | 8.96 | 0.0031 |
| HIST1H2BM | Histone cluster 1, H2bm | NM_003521 | 8.87 | 0.0125 |
| HIST1H3F | Histone cluster 1, H3f | NM_021018 | 8.77 | 0.0081 |
| ADAM12 | ADAM metallopeptidase domain 12 | NM_001288973 | 8.70 | 0.0121 |
| KIAA1199 | KIAA1199; NULL | NM_018689 | 8.48 | 0.0045 |
| COL10A1 | Collagen, type X, alpha 1 | NM_000493 | 6.87 | 0.0136 |
| DHCR7 | 7-Dehydrocholesterol reductase; NULL | NM_001360 | 6.51 | 0.0022 |
| P4HA3 | Prolyl 4-hydroxylase, alpha polypeptide III | NM_182904 | 6.49 | 0.0043 |
| LBP | Lipopolysaccharide binding protein | NM_004139 | 6.11 | 0.0021 |
| HAS1 | Hyaluronan synthase 1 | NM_001523 | 6.10 | 0.0038 |
| COL1A1 | Collagen, type I, alpha 1; NULL | NM_000088 | 5.94 | 0.000002 |
| NDNF | Neuron-derived neurotrophic factor | NM_024574 | 5.75 | 0.0147 |
| ELN | Elastin; NULL | NM_000501 | 5.65 | 0.0014 |
| WISP1 | WNT1 inducible signaling pathway protein 1 | NM_003882 | 5.61 | 0.0052 |
| ADAM12 | ADAM metallopeptidase domain 12; NULL | NM_003474 | 5.56 | 0.0008 |
| KDELR3 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 | NM_016657 | 5.36 | 0.0085 |
| HIST1H3I | Histone cluster 1, H3i | NM_003533 | 5.02 | 0.0014 |
| CNN1 | Calponin 1, basic, smooth muscle | NM_001299 | 4.69 | 0.00001 |
| Downregulated genes | ||||
| HLA-DRA | Major histocompatibility complex, class II, DR alpha | NM_019111 | −553.64 | 0.0005 |
| GBP4 | Guanylate binding protein 4 | NM_052941 | −244.27 | 0.0001 |
| HLA-DRA | Major histocompatibility complex, class II, DR alpha; NULL | ENST00000442960 | −188.10 | 0.00005 |
| CXCL9 | Chemokine (C-X-C motif) ligand 9 | NM_002416 | −96.44 | 0.00001 |
| IDO1 | Indoleamine 2,3-dioxygenase 1 | NM_002164 | −76.98 | 0.00004 |
| HLA-DRB3 | Major histocompatibility complex, class II, DR beta 3 | ENST00000307137 | −70.87 | 0.0024 |
| GBP5 | Guanylate binding protein 5 | NM_052942 | −65.02 | 0.000004 |
| SECTM1 | Secreted and transmembrane 1; NULL | NM_003004 | −50.74 | 0.0001 |
| GBP2 | Guanylate binding protein 2, interferon-inducible | ENST00000464839 | −41.55 | 0.00001 |
| HLA-DPA1 | Major histocompatibility complex, class II, DP alpha 1 | NM_001242524 | −40.79 | 0.0011 |
| IFIT3 | Interferon-induced protein with tetratricopeptide repeats 3 | NM_001031683 | −39.52 | 0.0011 |
| CIITA | Class II, major histocompatibility complex, transactivator | NM_000246 | −37.92 | 0.000003 |
| GBP1 | Guanylate binding protein 1, interferon-inducible | NM_002053 | −35.79 | 0.0002 |
| PSAT1 | Phosphoserine aminotransferase 1 | NM_021154 | −31.20 | 0.0001 |
| HLA-DPB1 | NULL | OTTHUMT00000310634 | −28.81 | 0.00002 |
| GBP1P1 | Guanylate binding protein 1, interferon-inducible pseudogene 1 | ENST00000513638 | −27.87 | 0.00001 |
| GCH1 | GTP cyclohydrolase 1 | NM_000161 | −26.74 | 0.0002 |
| PARP14 | Poly (ADP-ribose) polymerase family, member 14 | NM_017554 | −26.49 | 0.0008 |
| IRF1 | Interferon regulatory factor 1 | NM_002198 | −24.92 | 0.000003 |
| HLA-DOA | Major histocompatibility complex, class II, DO alpha | NM_002119 | −24.00 | 0.00001 |
| RARRES3 | Retinoic acid receptor responder (tazarotene induced) 3 | NM_004585 | −23.10 | 0.0001 |
| LGALS17A | Charcot-Leyden crystal protein pseudogene | ENST00000412609 | −22.45 | 0.0003 |
| HLA-DOA | Major histocompatibility complex, class II, DO alpha | NM_002119 | −21.85 | 0.00001 |
| SLC7A11 | Solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | NM_014331 | −21.62 | 0.00004 |
| USP30-AS1 | USP30 antisense RNA 1 | ENST00000478808 | −20.00 | 0.0001 |
| HCP5 | HLA complex P5 (non-protein coding); NULL | ENST00000457127 | −19.90 | 0.0001 |
| ICAM1 | Intercellular adhesion molecule 1 | NM_000201 | −19.63 | 0.0001 |
| WARS | Tryptophanyl-tRNA synthetase; NULL | NM_004184 | −19.41 | 0.0001 |
| APOL1 | Apolipoprotein L, 1; NULL | NM_003661 | −19.36 | 0.00002 |
| ERVK-7 | Endogenous retrovirus group K, member 7; novel transcript | ENST00000522373 | −18.93 | 0.0267 |
| HLA-DPB2 | Major histocompatibility complex, class II, DP beta 2 (pseudogene) | NR_001435 | −18.91 | 0.00009 |