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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Cell Rep. 2014 Jan 9;6(2):357–365. doi: 10.1016/j.celrep.2013.12.024

Fig. 5. Dityromycin blocks the transition from pre- to post-translocational conformations of EF-G.

Fig. 5

(A) The left panel shows a cross section of the ribosome (30S yellow, 50S light blue) with dityromycin (red) and S12 (blue) highlighted. The right panel shows the same view, but with EF-G (green) bound in the post translocational conformation (Gao et al., 2009a), PDB accession code 2WRI. (B) Close-up view of the clash between dityromycin and EF-G bound in the post translocational conformation. (C) Schematic of translocation and its inhibition by dityromycin/GE82832. The 50S (light blue) and 30S (yellow) subunits, deacylated tRNA (light brown), peptidyl tRNA (light grey) and S12 (blue) are shown, along with EF-G (green with domains I–V indicated) and dityromycin (red).