Table 1.

Demographic features and perioperative variables of the 2 groups

Variables	Placebo (group I, n=30)	NAC (group II, n=30)	P
Age, years	70.50 (68.00–73.25)	71.50 (69.00–73.50)	0.212
Male, n, %	73	60	0.281
BMI, kg/m2	28.27 (26.75–30.40)	25.03 (22.84–28.20)	0.015
LVEF, %	56.50	60.00	0.424
DM, n, %	47	50	0.800
HT, n, %	57	43	0.310
PAD, n, %	13	10	0.694
Smoking, n, %	53	37	0.201
ACE Inh., n, %	23	27	0.770
Duration of
surgery, min	240 (235–270)	220 (210–250)	0.434
CPB time, min	99.33±22.50	91.47±22.06	0.362
Cross-clamp
time, min	54.00 (43.25–60.00)	49.00 (39.25–62.00)	0.626
Bleeding, mLa	545 (380–713)	565 (438–700)	0.506
Red blood cells,
Unitsb	1.70±0.84	1.30±1.01	0.073
Urine output, mL
PO day 1	2913±471	2982±534	0.599
PO day 2	2816±353	2674±436	0.170
Volume, mLc	3330 (3088–3515)	3100 (2900–3500)	0.346
Bradycardiad, n, %	10.00	6.67	0.647
Hypotensiond, n, %	20	20	1.000
ICU stay, days	1.57±0.50	1.63±0.61	0.648
Inotropic drug, n, %	27	20	0.549
IABP, n, %	6.67	3.33	0.561
Hospital stay, days	5.93±1.17	6.20±1.16	0.379
Preoperative
creatinine, mg/dL	0.98±0.19	0.93±0.24	0.402
NGAL, ng/mL	64.13±20.78	55.24±24.69	0.137

ACE Inh. - angiotensin-converting enzyme inhibitors; BMI - body mass index; CPB - cardiopulmonary bypass; DM - diabetes mellitus; HT - hypertension; IABP - intra-aortic balloon pump; ICU - intensive care unit; LVEF - left ventricular ejection fraction; NAC - N-acetyl cysteine; NGAL - neutrophil gelatinase-associated lipocalin; PAD - peripheral arterial disease; PO - postoperative;

^atotal bleeding during the first 24 h postoperatively;

^btotal units of packed red blood cell transfusion during intensive care unit follow-up;

^ctotal amount of volume received during the first 24 h postoperatively;

^dan episode longer than 10 min

Student’s t-test, Mann–Whitney U test, and chi-square test were used for the comparison of groups