Figure 5.

Effects of bvPLA2 on histological changes in AD-like skin lesions of CD25 depleted mice. (A) Representative ear section images were stained with H&E to assess the histological changes (×200 magnification); (B) the thicknesses of epidermis; and (C) dermis were quantified based on the H&E stained sections using Image Pro-Plus 5.1 software as described in the Materials and Methods; (D) Evaluation of ear histological change severity was quantified using a five-point score system. The statistical analyses were conducted with a one-way ANOVA followed by Newman-Keuls multiple comparisons test (*** p < 0.001 and * p < 0.05 and ^## p < 0.01 and ^# p < 0.05; not significant = ns, n = 3).