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Ribotoxins as immunotherapeutic agents. (A) General structure of an immunotoxin, composed of a specific antibody fragment responsible for targeting to a specific cell type linked to a toxin moiety, ribotoxins or non-toxic ribonucleases like RNase T1, which promote cell death; (B) IMTXA33αs, an immunotoxin that contains α-sarcin as the toxic domain, has been tested in nude mice.
