Figure 5.

The effect of a paternal high fat diet with exercise interventions on the expression of pancreatic microRNAs in male offspring. The expression of microRNA (A) let7d-5p and (B) 194-5p in the pancreases of male offspring was reduced by a paternal HFD and restored by an exercise intervention to an abundance that was not different to that of offspring sired by CC-fed fathers; (C) the number of differentially expressed microRNAs between groups and the number of differential microRNAs in common between groups. Data is presented as mean fold change ± standard error mean by ΔΔC_t (A,B) or number of microRNAs (C). n = 4 male offspring; representative of n = 4 fathers per group. ^{a, b} Different letters denote significant difference at p < 0.05.