Table 2.

Anticancer activity of GS in in vivo animal experimental models

Cancer Type	Model/System	Antitumor effects	References
Pancreatic cancer	Pancreatic cancer cell line xenograft tumors	↓ tumor size	[39]
Colon Cancer	HT-29 xenograft tumors	↓ tumor size	[50]
Esophageal cancer	Esophageal adenocarcinoma cell lines	↓ tumor size	[47]
Breast cancer	MCF7 xenograft tumors	↓Bcl-2 and P-glycoprotein expression ↑Chemosensivity of doxorubicin in vivo	[75]
Prostate cancer	DU145 prostate cancer cells implanted in mouse	↓ tumor size, ↓ angiogenesis↓ VEGFR-2	[28]