Figure EV2. An antiparallel contact between the EI and LI fusion domains.

• A
  Views of the antiparallel contact between the EI and LI fusion domains in the tetrameric crystal structure. CHAV G_th LI is in brown, and CHAV G_th EI is in blue. Hydrophobic residues in the fusion loops are in pink sticks. Glycan chains are also represented in a sticks model. The inset shows a zoom on one of the intermolecular EI/LI beta sheets. Sites of mutations previously reported to affect the fusion properties are boxed. Side chains that cluster together (including H80, E112, D121, E123) in the interface on the sheet's face opposite the EI's fusion loops are shown as sticks and labeled, with for LI residues.
• B, C
  Localization of residues H80, E112, D121, E123 in the fusion domain in the pre‐fusion (B) and post‐fusion (C) conformations of VSV G.