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. 2016 Dec 10;3(2):261–271. doi: 10.1016/j.jcmgh.2016.11.006

Figure 2.

Figure 2

Suppression of CYP7A1 by ER stress is independent of known bile acid regulatory pathways. (A) Relative ileal Fgf15 mRNA expression and (B) relative hepatic Shp, tumor necrosis factor (Tnf)α, Il1β, and Il6 mRNA expression in mice treated with tunicamycin (Tm) for 6 hours. Means (n = 6) ± SD. *P < .05 vs control. (C and D) Relative CYP7A1 mRNA levels in HepG2 cells treated with (C) Tm ± JNK-inhibitor (SP600125) or (D) tunicamycin ± MAPK/ERK kinase inhibitor (PD184352) for 6 hours. Means (n = 6) ± SD. *P < .05 vs control cells not treated with Tm, #P < .05 vs control cells not treated with inhibitor.