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. 2016 Dec 10;3(2):261–271. doi: 10.1016/j.jcmgh.2016.11.006

Figure 4.

Figure 4

Effect of prolonged ER stress on bile acid metabolism. (A) Relative hepatic mRNA expression of Cyp7a1, Abcc3, Abcb11, and Ntcp, (B) hepatic cholesterol content (mg chol/g liver), (C) hepatic bile acid content (mmol/g liver), (D) hepatic bile acid composition (% of total hepatic bile acids), (E) relative hepatic mRNA expression of tumor necrosis factor (Tnf)α, IL1β, and IL6, (F) plasma alanine aminotransferase (ALT) level (IU/L), and (G) H&E-stained liver sections of mice treated with tunicamycin for 5 days. Means (n = 6) ± SD. *P < .05 vs vehicle-injected controls. Con, control; TCA, taurocholic acid; TCDCA, taurochenodeoxycholic acid; Tm, tunicamycin; TMCA, tauromuricholic acid.