FIG 10.

BRD4 plays a central role in transcriptional elongation in the mucosal innate immune response. Schematic diagram. Pattern recognition receptors RIG-I and TLR3 trigger the acetyl histone reader BRD4 to complex with CDK9 and NF-κB/RelA. The function of BRD4 is required for the mucosal inflammatory response, amplification of IRF1/7-RIG-I amplification loop, and ISG regulatory network bridging CDK9 recruitment and formation of phospho-Ser 2 CTD RNA Pol II. In this manner, BRD4 mediates mucosal inflammation to viral patterns in vivo.