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The M21T mutation did not enhance production of Jc1 virus. Huh7.5.1 cells were electroporated with in vitro-transcribed WT, M21T mutant, or GND mutant JFH1 or Jc1 RNA. Transfected cells were analyzed for HCV E2 immunofluorescence at day 2 postelectroporation (A) and intracellular HCV RNA levels (B), and supernatant infectivity titers were determined at different time points after electroporation (C). Error bars indicate standard deviations calculated from 3 independent experiments.
