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VSVΔG-CHIKV, VSVΔG-H5N1, and VLV are safe in the adult brain, whereas VSVΔG-Nipah F+G is lethal. (A) Of the 4 viruses tested, only VSVΔG-Nipah F+G was rapidly lethal when injected into the adult mouse brain. VSVΔG-CHIKV, VSVΔG-H5N1, and VLV were all completely without lethal effect in the adult brain. (B) In contrast to its lack of adverse action in the adult brain, VSVΔG-H5N1 showed lethal actions when injected into the brains of younger, postnatal day 14 mice.
