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PB1-V43I substitution leads to distortion of viral promoter position. Structures A and B show the homology models, respectively, of the wild-type (peptide is shown in silver) and V43I mutant (peptide is shown in orange) PR8 PB1 polymerase (amino acids 1 to 314). The viral RNAs are shown in black (A) and magenta (B). The Val-43 and the Ile-43 residues are indicated as space-filling Corey-Pauling-Koltun models. An overlay of the structures is shown in panel C.
