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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: J Mol Biol. 2015 Jan 30;427(11):2088–2103. doi: 10.1016/j.jmb.2015.01.016

Fig. 7.

Fig. 7

Fps1p positively regulates the Sho1p branch of the HOG pathway. Hyperosmotic stress triggers the activation of the Sho1p and Sln1p branches of the HOG pathway. (a) The presence of Fps1p positively regulates the Sho1p branch, possibly by binding to the SH3 domain of Sho1p, resulting in the phosphorylation of downstream Hog1p and osmoadaptation of the cell. (b) Fps1p may also positively regulate the Sln1p branch by an unidentified mechanism. (c) It is also possible that there exists a yet uncharacterized Sho1p- and Sln1p-independent pathway of Hog1p regulation by Fps1p.