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. 2017 Feb 20;10(1):e001598. doi: 10.1161/CIRCGENETICS.116.001598

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© 2016 The Authors.

Circulation: Cardiovascular Genetics is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDervis License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 5. — Hyaluronidase 2 (HYAL2) distribution in embryonic hearts. Sections of the embryonic heart at embryonic day (E) 8.5, from a previous study,¹⁹ were used for the detection of HYAL2 using immunofluorescent and immunohistochemical approaches. A–C, Detection of HYAL2 (red) in the endocardial lining of the blood vessels of the E8.5 heart. Nuclei are stained blue with Hoechst 33342. D–F, Enlarged view of the image in (A)–(C). G–J, HYAL2 distribution in E14.5 and E18.5 embryos. The brown staining indicates the presence of HYAL2 in the endothelial cells of blood vessels and heart valves of wild-type heart at E14.5 (H; n=3) and E18.5 (J; n=3), respectively. As expected, this signal is absent in the Hyal2^−/− hearts (G and I; n=3). Bar=50 μm.