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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Nat Genet. 2016 Jun 20;48(8):856–866. doi: 10.1038/ng.3598

Figure 4.

Figure 4

Enrichment of the migraine loci in sets of tissue-specific enhancers. We mapped credible sets from the migraine loci to sets of enhancers under active expression in 56 tissues and cell lines (identified by H3K27ac histone marks from the Roadmap Epigenomics65 and ENCODE66 projects). Enrichment P-values were assessed empirically by randomly generating a background set of matched loci for comparison (10,000 replicates) and the vertical dotted line is the significance threshold after adjusting for 56 separate tests by Bonferroni correction (see Online Methods).