Figure 2.
Metabolic gene expression studies in visceral adipose tissue depot. (A) Quantitative RT-PCR demonstrated a significant relative fold increase in gene expression for both LPL and ATGL in the SIGFRKO vs control mice; an increase in HSL expression was also detected, but did not reach significance. (B) In contrast, a decrease in FAS expression was measured in SIGFRKO vs control mice. Although there was a trend for higher expression of GLUT4 and CIDE-A in SIGFRKO mice, results did not reach significance. (C) No differences in leptin gene expression were seen between the two groups; however, adiponectin levels were higher in the SIGFRKO mice. (* p<0.05, bars represent S.E.M.)
