Table 3.
Multivariable Model of Association Between Quality of Life Outcomes (minimum clinically important difference) and Clinical Variables
| OR | 95% CI | ||
|---|---|---|---|
| IPSS Overall | |||
| Fractionation (HIMRT vs CIMRT) | 0.97 | 0.57 | 1.65 |
| Year 1 | 0.82 | 0.53 | 1.25 |
| Year 2 | 0.89 | 0.57 | 1.38 |
| Year 3 | 0.85 | 0.53 | 1.37 |
| Year 4 | 1.12 | 0.69 | 1.82 |
| Year 5 | 1.09 | 0.64 | 1.87 |
| Year 6 | 0.57 | 0.24 | 1.36 |
| Year 7 | 0.79 | 0.35 | 1.79 |
| Age (Continuous) | 0.94 | 0.91 | 0.98 |
| LN Radiation (Yes vs No) | 1.12 | 0.48 | 2.58 |
| ADT Use (No vs Yes) | 1.21 | 0.56 | 2.63 |
| IPSS Quality of Life | |||
| Fractionation (HIMRT vs CIMRT) | 0.77 | 0.43 | 1.38 |
| Year 1 | 1.05 | 0.70 | 1.57 |
| Year 2 | 1.23 | 0.81 | 1.86 |
| Year 3 | 1.02 | 0.65 | 1.60 |
| Year 4 | 1.27 | 0.80 | 2.01 |
| Year 5 | 1.48 | 0.88 | 2.48 |
| Year 6 | 1.38 | 0.57 | 3.37 |
| Year 7 | 0.87 | 0.35 | 2.14 |
| Age (Continuous) | 0.99 | 0.96 | 1.03 |
| LN Radiation (Yes vs No) | 1.36 | 0.52 | 3.54 |
| ADT Use (No vs Yes) | 1.55 | 0.65 | 3.74 |
| EPIC Urinary Incontinence | |||
| Fractionation (HIMRT vs CIMRT) | 1.88 | 0.95 | 3.72 |
| Year 1 | 1.14 | 0.55 | 2.38 |
| Year 2 | 1.22 | 0.56 | 2.68 |
| Year 3 | 0.87 | 0.39 | 1.94 |
| Year 4 | 1.08 | 0.49 | 2.38 |
| Year 5 | 0.71 | 0.30 | 1.69 |
| Age (Continuous) | 0.97 | 0.92 | 1.01 |
| LN Radiation (Yes vs No) | 1.57 | 0.54 | 4.59 |
| ADT Use (No vs Yes) | 0.89 | 0.33 | 2.36 |
| EPIC Urinary Irritative/Obstructive | |||
| Fractionation (HIMRT vs CIMRT) | 0.45 | 0.12 | 1.69 |
| Year 1 | 1.02 | 0.32 | 3.30 |
| Year 2 | 0.73 | 0.22 | 2.40 |
| Year 3 | 0.73 | 0.22 | 2.47 |
| Year 4 | 1.14 | 0.34 | 3.88 |
| Year 5 | 1.20 | 0.33 | 4.32 |
| Age (Continuous) | 0.99 | 0.92 | 1.07 |
| LN Radiation (Yes vs No) | 1.59 | 0.21 | 11.90 |
| ADT Use (No vs Yes) | 0.19 | 0.03 | 1.37 |
| EPIC Sexual | |||
| Fractionation (HIMRT vs CIMRT) | 3.31 | 0.61 | 17.82 |
| Year 1 | 0.19 | 0.05 | 0.76 |
| Year 2 | 0.80 | 0.23 | 2.76 |
| Year 3 | 0.62 | 0.17 | 2.30 |
| Year 4 | 0.60 | 0.17 | 2.16 |
| Year 5 | 0.92 | 0.24 | 3.56 |
| Age (Continuous) | 0.10 | 0.01 | 0.73 |
| LN Radiation (Yes vs No) | 50.48 | 4.01 | 634.76 |
| ADT Use (No vs Yes) | 0.93 | 0.83 | 1.04 |
| EPIC Hormonal | |||
| Fractionation (HIMRT vs CIMRT) | 1.08 | 0.51 | 2.29 |
| Year 1 | 1.76 | 0.75 | 4.12 |
| Year 2 | 3.28 | 1.37 | 7.86 |
| Year 3 | 3.27 | 1.31 | 8.15 |
| Year 4 | 3.28 | 1.32 | 8.13 |
| Year 5 | 4.36 | 1.71 | 11.12 |
| Age (Continuous) | 0.44 | 0.17 | 1.16 |
| LN Radiation (Yes vs No) | 2.70 | 0.99 | 7.38 |
| ADT Use (No vs Yes) | 0.97 | 0.93 | 1.02 |
| EPIC Bowel | |||
| Fractionation (HIMRT vs CIMRT) | 0.78 | 0.25 | 2.41 |
| Year 1 | 0.41 | 0.15 | 1.10 |
| Year 2 | 0.52 | 0.19 | 1.44 |
| Year 3 | 1.83 | 0.71 | 4.77 |
| Year 4 | 1.29 | 0.48 | 3.45 |
| Year 5 | 1.19 | 0.42 | 3.38 |
| Age (Continuous) | 0.99 | 0.92 | 1.07 |
| LN Radiation (Yes vs No) | 0.56 | 0.09 | 3.33 |
| ADT Use (No vs Yes) | 2.47 | 0.47 | 12.91 |
| EQ5D VAS | |||
| Fractionation (HIMRT vs CIMRT) | 0.78 | 0.14 | 4.46 |
| Year 1 | 5.61 | 1.80 | 17.54 |
| Year 2 | 2.79 | 0.85 | 9.20 |
| Year 3 | 2.18 | 0.65 | 7.38 |
| Year 4 | 1.81 | 0.54 | 6.06 |
| Year 5 | 3.19 | 0.91 | 11.21 |
| Age (Continuous) | 0.98 | 0.88 | 1.10 |
| LN Radiation (Yes vs No) | 1.92 | 0.12 | 32.06 |
| ADT Use (No vs Yes) | 0.63 | 0.05 | 8.35 |
| EQ5D Index | |||
| Fractionation (HIMRT vs CIMRT) | 0.44 | 0.13 | 1.54 |
| Year 1 | 1.51 | 0.50 | 4.56 |
| Year 2 | 3.61 | 1.18 | 11.07 |
| Year 3 | 1.50 | 0.47 | 4.78 |
| Year 4 | 3.06 | 0.94 | 9.92 |
| Year 5 | 0.91 | 0.26 | 3.24 |
| Age (Continuous) | 0.91 | 0.84 | 0.98 |
| LN Radiation (Yes vs No) | 1.44 | 0.22 | 9.48 |
| ADT Use (No vs Yes) | 3.07 | 0.52 | 18.24 |