Table 5. . Estimates of natural direct and natural indirect effects of sustained maternal smoking, assessed by cotinine-enhanced self-report, on birth weight and proportion mediated by CpGs cg09935388 in GFI1 in both naive analyses and after SIMEX correction for measurement error in the Norwegian Mother and Child Study.
| CpG | SN | NDE (95% CI) | NIE (95% CI) | PM |
|---|---|---|---|---|
| cg09935388 | Naive | -89.4 (-179.5 to 2.6) | -27.8 (-59.7 to 5.1) | 0.24 |
| 0.6 | -106.9 (-216.4 to 8.1) | -18.7 (-60.4 to 21.7) | 0.15 | |
| 0.7 | -102.1 (-205.9 to 16.2) | -21.5 (-60.8 to 17.6) | 0.17 | |
| 0.8 | -97.9 (-195.5 to 4.2) | -23.9 (-59.6 to 11.9) | 0.20 | |
| 0.9 | -92.2 (-184.0 to -0.9) | -25.7 (-59.1 to 8.3) | 0.22 |
The SIMEX corrected values are presented for four different values for sensitivity of the self-reported maternal smoking exposure variable: 0.6, 0.70, 0.80, 0.90 where specificity = 1. Median and 95% percentile CIs for the bootstrap estimates are in units of grams of birth weight
NDE: Natural direct effect; NIE: Natural indirect effect; SN: Sensitivity; PM: Proportion mediated.