Table 6. Linear Regression Analysis Forward Method.

Cognitive domain	Phe average				Phe variation
	Full-model	Significant variable/s	R2	B	Full- model	Significant variable/s	R2	B
Note. Performance in different cognitive domains predicted by Phe average or Phe variation for different developmental epochs: early childhood (up to 10 years) adolescence (11–16) and adulthood (17+); measures of current Phe and life span Phe measures are also included. B shows changes in performance measures for every 100 μmol/l of Phe (e.g., for visuo-motor coordination, .2 z scores are added for every 100 μmol/l of phe; for IQ, 14 point of IQ are lost for every 100 μmol/l of Phe.
Full Scale IQ	ns				.001	Lifetime Phe	.34	.14
Visuo-spatial attention	.03	Childhood Phe	.16	.1	.04	Childhood Phe	.14	.4
Visuo motor coordination	.01	Current Phe	.22	.2	.005	Lifetime Phe	.25	1.3
Complex executive functions	.03	Adolescence Phe	.16	.1	.006	Childhood Phe	.24	.9
Inhibitory control	ns				ns
Short-term memory	ns				ns
Sustained attention	.006	Current Phe	.24	.2	.03	Adult Phe	.16	.8
Orthographic language	ns				ns
Spoken language	ns				.003	Adolescence Phe	.28	.8
Verbal memory and learning	<.001	Current Phe	.44	.2	.02	Childhood Phe	.21	.6
Visuo-spatial memory and learning	.002	Adolescence Phe	.32	.2	<.001	Childhood Phe	.36	1.2