Table 1.
General characteristics of the 580 unselected men and women stratified according to the presence of resistant hypertension (RH). BMI: body mass index. SUA: serum uric acid; SBP, DBP: systolic and diastolic blood pressure; HR: heart rate; TC, HDLC, LDL: total, high-density- and low-density-lipoprotein serum cholesterol; TG: serum triglycerides; ATH: anti-hypertensive; ABPM: ambulatory blood pressure monitoring. NS: non-significant difference.
| Items | All subjects (n = 580) |
Without RH (n = 547) |
With RH (n = 33) |
p-value |
|---|---|---|---|---|
| Age (yrs) | 73.2 ± 4.8 | 73.1 ± 4.8 | 73.7 ± 5.2 | NS |
| Female gender (%) | 53.1 | 51. 6 | 78.8 | <0.05 |
| BMI (kg/m2) | 26.7 ± 3.7 | 26.7 ± 3.8 | 27.0 ± 3.0 | NS |
| Obesity (%) | 49.5 | 46.2 | 3.3 | NS |
| SUA (mg/dl) | 5.29 ± 1.4 | 5.26 ± 1.4 | 5.80 ± 1.6 | <0.05 |
| SUA >6.8 mg/dl (%) | 20.3 | 17. 7 | 63.6 | <0.05 |
| Clinic BP values | ||||
| SBP (mmHg) | 143.3 ± 18.4 | 141.3 ± 16.6 | 158.2 ± 4.7 | <0.05 |
| DBP (mmHg | 79.6 ± 11.6 | 79.8 ± 11.6 | 77.1 ± 0.3 | NS |
| HR (bpm) | 71.8 ± 9.6 | 71.9 ± 9.5 | 71.2 ± 11.7 | NS |
| 24-h ABPM values | ||||
| SBP (mmHg) | 137.9 ± 13.6 | 137.4 ± 13.7 | 146.6 ± 9.2 | <0.05 |
| DBP (mmHg) | 76.8 ± 6.7 | 76.9 ± 6.7 | 75.7 ± 6.5 | NS |
| HR (bpm) | 71.2 ± 8.0 | 71.6 ± 8.2 | 68.1 ± 6.8 | NS |
| Day-time SBP (mmHg) | 141.1 ± 13.8 | 140.4 ± 13.8 | 151.6 ± 8.7 | <0.05 |
| Day-time DBP (mmHg) | 78.8 ± 7.0 | 78.9 ± 7.2 | 90.2 ± 4.6 | NS |
| Day-time HR (bpm) | 73.2 ± 8.2 | 73.4 ± 8.1 | 70.0 ± 7.7 | NS |
| Night-time SBP (mmHg) | 126.5 ± 16.4 | 126.5 ± 16.6 | 128.7 ± 11.1 | NS |
| Night-time DBP (mmHg) | 70.0 ± 8.4 | 70.1 ± 8.5 | 67.9 ± 7.5 | NS |
| Night-time HR (bpm) | 64.5 ± 8.6 | 64.4 ± 8.6 | 64.0 ± 8.1 | NS |
| Diuretic treatment (%) | 23.8% | 19.2% | 10 0 | <0.05 |
| Number of ATH-drugs | 1.0 ± 1.24 | 0.8 ± 0.9 | 4.2 ± 0.5 | <0.05 |
| Serum glucose (mg/dl) | 102.1 ± 25.1 | 102.6 ± 25.4 | 104.4 ± 18.6 | NS |
| Diabetes (%) | 18.8 | 18.5 | 24.2 | NS |
| Serum creatinine (mg/dl) | 0.92 ± 0.32 | 0.92 ± 0.34 | 0.99 ± 0.31 | NS |
| eGFR (ml/min) | 68.3 ± 16.8 | 62.2 ± 16.7 | 60.1 ± 16.9 | <0.05 |
| Uricosuric drugs (%) | 9.4 | 13.4 | 4.2 | <0.05 |
| Proteinruia (%) | 14.3 | 11. 6 | 17. 8 | NS |
| LVH (%) | 45 | 38.7 | 52.6 | <0.05 |
| TC (mg/dl) | 206.4 ± 70.6 | 200.6 ± 72.1 | 210.8 ± 41.2 | NS |
| HDLC (mg/dl) | 61.2 ± 16.0 | 61.3 ± 16.2 | 60.1 ± 14.3 | NS |
| TG (mg/dl) | 114.4 ± 63.6 | 113.3 ± 64.4 | 133.2 ± 45.4 | <0.05 |
| LDCL (mg/dl) | 120.1 ± 33.7 | 120.5 ± 33.6 | 121.5 ± 34.5 | NS |
| Smoking (%) | 6.7 | 6.9 | 3.0 | NS |
| Ethanol (g/week) | 28.4 ± 21.9 | 27.44 ± 20.0 | 29.2 ± 23.5 | NS |