. 2017 Mar 1;12(3):e0172175. doi: 10.1371/journal.pone.0172175

Table 3. Main Analysis.

Hazard Ratio (95% CI) of first VF (n = 19,324 / 10, 534 failures).

Medication Exposure Mode	Bias Correction		Statins	Non-Statin Lipid—lowering Agents	Antihyper-tensives	Cardiac Aspirin
PDC (30/90d)^*	None		0.57 (0.53–0.62)	0.76 (0.69–0.83)	0.79 (0.75–0.83)	0.83 (0.76–0.90)
	None		p<0.001	p<0.001	p<0.001	p<0.001
	Multivariate Adjustment		0.83 (0.76–0.90)	1.03 (0.94–1.14)	1.00 (0.95–1.05)	1.10 (1.01–1.21)
	Multivariate Adjustment		p<0.001	p = 0.5	p = 0.85	p = 0.04
Current Use (within 7 d)	None		0.60 (0.56–0.65)	0.76 (0.70–0.83)	0.82 (0.79–0.86)	0.88 (0.81–0.95)
	None		p<0.001	p<0.001	p<0.001	p = 0.002
	Multivariate Adjustment		0.81 (0.75–0.88)		0.97 (0.89–1.06)	1.00 (0.96–1.05)	1.13 (1.04–1.23)
	Multivariate Adjustment		p<0.001		p = 0.53	p = 0.9	p = 0.004
	IPW	Truncation
		<5% / >95%	0.76 (0.69–0.83)	0.97 (0.88–1.08)	0.98 (0.94–1.03)	1.01 (0.91–1.12)
		<5% / >95%	p<0.001	p = 0.64	p = 0.46	p = 0.86
		<1% / >99%	0.83 (0.75–0.92)	1.03 (0.92–1.15)	1.02 (0.97–1.07)	1.03 (0.92–1.15)
		<1% / >99%	p<0.001	p = 0.67	p = 0.57	p = 0.63
		<0.1%/>99.9%	0.90 (0.80–1.01)	1.04 (0.93–1.17)	1.03 (0.98–1.08)	1.04 (0.92–1.16)
		<0.1%/>99.9%	p = 0.08	p = 0.48	p = 0.29	p = 0.57

All hazard ratios (HR) are followed by 95% confidence intervals in parenthesis. PDC: percentage of days covered, IPW: Inverse Probability Weighting for treatment and censoring.

*PDC interval 30 days for statins/CVMs and 90 days for ARVs. In PDC mode, HR is for 100% use.