Fig 3. Quantitative analysis of the BMP9-induced calvarial defect repair.
(A, B, C) Average defect volumes (mm3) were calculated at 24–48 hours, 2, 4, 6, 8, and 12 weeks postoperatively using volumetric reconstructions generated in Amira®. Asterisks indicate a significant (p < 0.05) difference in average defect volume between test groups at the specified time point, as determined by one-way ANOVA. (D, E, F) The change in defect volume over time was used to deduce the percentage of baseline defect volume filled with new bone.