Table 3. Damaging nsSNVs located in potential LC3 interacting regions.
| MOTIF | START | END | LIR sequence | TGM2 damaging nsSNV |
|---|---|---|---|---|
| xLIR | 352 | 357 | EGWQAL | • p.Glu352Lys • p.Gly353Val |
| WxxL | 38 | 43 | PFWLTL | • p.Leu43Arg |
| WxxL | 133 | 138 | GHFILL | • p.Leu137Phe |
| WxxL | 278 | 283 | WVFAAV | • p.Ala282Thr • p.Val283Met |
| WxxL | 392 | 397 | FVFAEV | • p.Ala395Val |
| WxxL | 514 | 519 | VSYNGI | • p.Asn517Ser |
| WxxL | 677 | 682 | KGFRNV | • p.Arg680Trp • p.Arg680Pro • p.Arg680Gln |
Column 1 represent the LIR and WxxL motifs, column 2 and 3 represent the start and end of each motif in TGM2, column 4 represent the sequence of LIR motifs and human TGM2 damaging nsSNVs are underlined in bold text.