Fig 5. Effect of pan-BET inhibitor JQ1 treatment on COPD patient derived lung resident alveolar macrophages and Peripheral Blood Mononuclear Cells (PBMC).

LPS-induced secretion of IL-6 (A) and GM-CSF (B) from from COPD patients and normal controls. PBMC from COPD patients were more sensitive to LPS stimulation producing higher levels of cytokines. JQ1 (AZ13632807) treatment lead to a more potent inhibition of LPS-induced IL-6 secretion in alveolar macrophages from COPD patients than observed in PBMC (D), whereas inhibition of GM-CSF was identical in the three cellular systems (C).