Fig. 3. PAR4 deficiency is associated with enhanced anti-apoptotic signaling after IR.
(A–B) Immunoblot analysis for PAR4-downstream signaling indicates an increase in anti-apoptotic signaling response in the infarcted region of the PAR4 KO mice vs. the WT post-IR. Top: Representative immunoblots. Bottom: Quantification of experiments represented as fold change compared to WT animals (n=6 for each groups). GAPDH was included as a loading control. *P<0.05 vs. WT shams, †P<0.05 vs. WT IR.