Table 1. List of genes involved in DNA damage signaling in the PCR array analysis, and the fold change of expressions after bleomycin treatment in space and on the ground.
Fold changes with a PCR cycle number >30 are left blank.
| Gene | Ground | Flight | Gene | Ground | Flight | ||||
|---|---|---|---|---|---|---|---|---|---|
| Fold | p value | Fold | p value | Fold | p value | Fold | p value | ||
| ABL1 | -1.11 | 0.21 | 1.01 | 0.9 | MPG | -1.08 | 0.16 | -1.06 | 0.24 |
| APEX1 | -1.08 | 0.34 | -1.07 | 0.15 | MRE11A | 1.04 | 0.84 | -1.01 | 0.87 |
| ATM | 1.13 | 0.68 | 1.04 | 0.78 | MSH2 | -1.04 | 0.9 | 1.12 | 0.31 |
| ATR | 1.04 | 0.86 | 1.08 | 0.6 | MSH3 | 1.03 | 0.83 | -1.02 | 0.84 |
| ATRIP | NBN | 1.05 | 0.81 | -1.05 | 0.64 | ||||
| ATRX | 1.24 | 0.56 | -1.11 | 0.35 | NTH L1 | -1.21 | 0.03 | 1.01 | 0.81 |
| BARD1 | -1.04 | 0.83 | -1.02 | 0.78 | OGG1 | 1.02 | 0.65 | -1.09 | 0.23 |
| BAX | -1.1 | 0.18 | -1.03 | 0.45 | PARP1 | 1.03 | 0.77 | 1.02 | 0.62 |
| BBC3 | 1.74 | 0 | 2.02 | 0.01 | PCNA | 1.45 | 0 | 1.32 | 0.04 |
| BLM | PMS1 | 1.09 | 0.76 | 1.02 | 0.93 | ||||
| BRCA 1 | PMS2 | -1.05 | 0.72 | -1.26 | 0.03 | ||||
| BRI P1 | 1.25 | 0.52 | -1.09 | 0.61 | PNKP | -1.22 | 0.09 | -1.01 | 0.9 |
| CDC25A | PPM1D | 1.98 | 0 | 1.77 | 0 | ||||
| CDC25C | PP P1R15A | -1.09 | 0.14 | -1.27 | 0.04 | ||||
| CDK7 | -1 | 0.98 | -1.08 | 0.18 | PRKDC | 1.06 | 0.74 | 1.04 | 0.65 |
| CDKN1A | 1.87 | 0 | 2.26 | 0.07 | RAD1 | -1.06 | 0.34 | -1.07 | 0.27 |
| CHEK1 | 1 | 0.97 | -1.06 | 0.5 | RAD17 | 1.12 | 0.61 | -1.07 | 0.55 |
| CHEK2 | -1.16 | 0.18 | -1.15 | 0.02 | RAD18 | -1.04 | 0.77 | -1.09 | 0.15 |
| CIB1 | -1.12 | 0.02 | -1.02 | 0.51 | RAD21 | 1.01 | 0.95 | -1.04 | 0.69 |
| CRY1 | 1.06 | 0.69 | -1.07 | 0.29 | RAD50 | 1.06 | 0.81 | -1.05 | 0.61 |
| CSNK2A2 | 1.07 | 0.44 | 1.01 | 0.82 | RAD51 | -1.06 | 0.37 | 1.05 | 0.61 |
| DDB1 | -1.04 | 0.36 | 1.02 | 0.66 | RAD51B | -1 | 0.94 | -1.11 | 0.02 |
| DDB2 | 1.07 | 0.25 | 1.12 | 0.09 | RA D9A | ||||
| DDIT3 | 1.04 | 0.64 | 1 | 0.95 | RBBP8 | 1.03 | 0.86 | 1.02 | 0.88 |
| ERCC1 | -1.09 | 0.14 | 1.02 | 0.73 | REV1 | 1.01 | 0.97 | -1.01 | 0.94 |
| ERCC2 | -1.23 | 0.21 | 1.03 | 0.63 | RN F168 | -1.03 | 0.92 | -1.09 | 0.41 |
| EXO1 | RN F8 | 1.04 | 0.74 | 1.01 | 0.8 | ||||
| FA NCA | RPA1 | -1.05 | 0.53 | 1 | 0.99 | ||||
| FANCD2 | SIRT1 | 1.1 | 0.59 | -1.12 | 0.37 | ||||
| FANCG | SMC1A | 1.13 | 0.43 | 1.02 | 0.8 | ||||
| FEN1 | -1.07 | 0.34 | 1.18 | 0.2 | SUMO1 | 1.08 | 0.58 | -1.07 | 0.25 |
| GADD45A | 1.17 | 0.29 | 1.17 | 0.08 | TOPBP 1 | 1.12 | 0.66 | -1.05 | 0.69 |
| GADD45G | TP53 | 1.06 | 0.45 | -1.05 | 0.34 | ||||
| H2AFX | -1.07 | 0.41 | 1.04 | 0.72 | TP53BP1 | 1 | 0.99 | -1 | 0.97 |
| HUS1 | 1.05 | 0.74 | -1.1 | 0.34 | TP73 | ||||
| LI G1 | UNG | -1.1 | 0.32 | 1.12 | 0.21 | ||||
| MAPK12 | -1.18 | 0.06 | -1.05 | 0.38 | XPA | ||||
| MBD4 | 1.14 | 0.55 | 1.05 | 0.47 | XPC | ||||
| MCPH1 | 1 | 0.96 | -1.02 | 0.63 | XRCC1 | -1.18 | 0.07 | -1 | 1 |
| MDC1 | -1.04 | 0.82 | 1.01 | 0.89 | XRCC2 | ||||
| MLH1 | -1.02 | 0.95 | 1.01 | 0.9 | XRCC3 | ||||
| MLH3 | -1.01 | 1 | -1.13 | 0.29 | XRCC6 | -1.05 | 0.42 | -1.01 | 0.77 |