Table 5. Upstream direct regulators identified by IPA in ground and flown cells in response to the bleomycin treatment.

	Upstream Regulator	Activation z-score	p-value of overlap	Target molecules in dataset
Flight	TP53	4.351	0.0000	AEN,BBC3,BDKRB2,BTG2,CDKN1A,EDA2R,FBXW7,FDXR, GAS1,GDF15,IER5,MAP3K8,MDM2,PCNA,PHLDA3,PMAIP1,PPM1D,SESN1, SESN2,TNFRSF10C,TNFSF9,TP53INP1, TRAF4
	TP73	2.476	0.0000	AEN,BBC3,BDKRB2,BTG2,CDKN1A,FDXR,MDM2,PMAIP1
	CREB1	1.982	0.0238	ACVR2A,BTG2,CDKN1A,PCNA
	RELA	1.932	0.0009	BBC3,BTG2,CDKN1A,GDF15,MDM2
	E2F1	1.907	0.0000	BBC3,CDKN1A,MDM2,PCNA,TNFSF9,TP53INP1,UXT
	HES1	-1.961	0.0000	BBC3,CDKN1A,MDM2,PCNA
Ground	TP53	4.161	0.0000	AEN,BBC3,BTG2,CDKN1A,CITED2,EDA2R,FBXW7,GDF15, IER5,MDM2,PANK1,PHLDA3,PIM1,PLK2,PMAIP1,PPM1D, RAP2B,SESN1,SESN2,TNFSF9, TOB1,TP53INP1,TRAF4
	TP73	2.288	0.0000	AEN,BBC3,BTG2,CDKN1A,MDM2,PMAIP1
	CTNNB1	1.964	0.0059	BBC3,CDKN1A,GDNF,SESN1,SRSF1
	RELA	1.932	0.0004	BBC3,BTG2,CDKN1A,GDF15,MDM2
	E2F1	1.46	0.0000	BBC3,CDKN1A,CITED2,MDM2,PLK2,SRSF1,TNFSF9, TP53INP1