Table 4.

Incidence of colon and rectal cancers according to asbestos exposure in the ARDCo‑Nut sample (Cox models, n = 3,579).

Exposure	Colon cancer						Rectal cancer
	Number		Univariate model		Final modela		Number		Univariate model		Final model
	n	C	HR (95% CI)	p-Value	HR (95% CI)	p-Value	n	C	HR (95% CI)	p-Value	HR (95% CI)	p-Value
CEI (exposure-unit years)
Ln(CEI) + 1	3,538	41	1.01 (0.84, 1.21)	0.946	1.07 (0.87, 1.32)	0.522	3,562	17	0.89 (0.67, 1.19)	0.443	0.90 (0.65, 1.24)	0.512
0–< 3	811	11	Ref	0.868b	Ref	0.912b	818	4	Ref	0.270b	NA	NA
3–< 20	912	10	0.83 (0.35, 1.96)	0.674	0.84 (0.33, 2.11)	0.708	914	8	1.78 (0.54, 5.92)	0.345	NA	NA
20–< 41	922	12	1.00 (0.44, 2.27)	0.997	1.07 (0.44, 2.57)	0.885	932	2	0.45 (0.08, 2.48)	0.361	NA	NA
≥ 41	893	8	0.72 (0.29, 1.79)	0.479	0.80 (0.30, 2.14)	0.662	898	3	0.74 (0.17, 3.32)	0.696	NA	NA
TSFE (continuous years)	3,538	41	0.99 (0.97, 1.04)	0.135	0.98 (0.96, 1.00)	0.074	3,562	17	0.99 (0.96, 1.03)	0.705	0.99 (0.96, 1.03)	0.774
0–20	155	1	Ref	0.0031b	Ref	0.004b	156	0	NA	NA	NA	NA
20–40	104	4	11.48 (1.24, 105.75)	0.031	11.45 (1.21, 108.44)	0.034	107	1	NA	NA	NA	NA
40–60	2,705	32	2.50 (0.33, 18.71)	0.372	2.46 (0.30, 20.19)	0.402	2,725	12	NA	NA	NA	NA
≥ 60	574	4	0.78 (0.09, 7.01)	0.821	0.69 (0.07, 7.03)	0.753	574	4	NA	NA	NA	NA
Note: C, overall number of incident colon or rectal cancer cases (update 30 April 2014); CEI, cumulative exposure index to asbestos; CI, confidence interval; HR, hazard ratio; n, overall numbers of participants by category; NA, not applicable; TSFE, time since first exposure (years). aModel adjusted on smoking, BMI, physical exercise, familial history of FAP or colorectal cancer in first-degree relatives, daily red meat and alcohol consumption. Models included separately both CEI and TSFE as categorical variables, or as continuous variables. bp-Value for trend test.