Table 3a.
Effect of acute and chronic GVHD on outcomes after single and double UCBT
| Single UCBT | Relapse | Non-Relapse Mortality | Disease-Free Survival | Overall Survival |
|---|---|---|---|---|
| Gr. 2–4 Acute GVHD | HR 0.69 (0.51–0.93) p = 0.014 |
HR 2.06 (1.47–2.88) p < 0.0001 |
HR 1.06 (0.86–1.32) p = 0.58 |
HR 1.08 (0.87–1.34) p = 0.50 |
| Gr. 3–4 Acute GVHD | HR 0.78 (0.53–1.15) p = 0.22 |
HR 2.75 (1.92–3.93) p < 0.0001 |
HR 1.38 (1.07–1.79) p = 0.014 |
HR 1.51 (1.17–1.95) p = 0.0017 |
| Chronic GVHD | HR 1.10 (0.74–1.63) p = 0.63 |
HR 1.53 (0.97–2.42) p = 0.068 |
HR 1.23 (0.91–1.65) p = 0.18 |
HR 0.96 (0.72–1.29) p = 0.82 |
| Double UCBT | Relapse | Non-Relapse Mortality | Disease-Free Survival | Overall Survival |
| Gr. 2–4 Acute GVHD | HR 0.87 (0.63–1.20) p = 0.39 |
HR 1.41 (1.05–1.90) p = 0.022 |
HR 1.11 (0.90–1.37) p = 0.34 |
HR 1.05 (0.86–1.30) p = 0.60 |
| Gr. 3–4 Acute GVHD | HR 0.68 (0.44–1.06) p = 0.084 |
HR 2.24 (1.66–3.04) p < 0.0001 |
HR 1.41 (1.11–1.79) p = 0.005 |
HR 1.48 (1.17–1.86) p = 0.001 |
| Chronic GVHD | HR 0.59 (0.36–0.96) p = 0.033 |
HR 1.49 (0.98–2.29) p = 0.065 |
HR 0.98 (0.71–1.33) p = 0.87 |
HR 0.95 (0.71–1.27) p = 0.70 |
Abbreviations: UCBT=Umbilical Cord Blood Transplant; GVHD = Graft-vs.-Host Disease; Gr. = Grade