Changes in intimal and medial cross-sectional area following graft implantation. (A) Significant time and flow dependent growth of the intima was observed (p<.001 time, p<.001 flow). Most notable was the difference in the intimal area of the low flow versus high and intermediate flow grafts, several weeks after implantation (Day 14: p=.009 low vs. intermediate, p<.001 low vs. high flow; Day 28: p<.001 low vs. intermediate, p<.001 low vs. high flow). (B) In contrast, the medial area demonstrates modest time dependent growth but is relatively unaffected by modulation of the flow. (p<.001 time, p=NS flow).