Within two hours following graft implantation, there was a significant reduction in mRNA expression of the SMC contractile phenotype markers TAGLN (p<.001), MYH11 (p<.001), and ACTA (p=.016), which was seen to nadir at Day 7. TAGLN and MYH11 expression were also dependent on the imposed hemodynamics (TAGLN: p<.001, MYH11: p<.035), with a sustained decrease in expression under high flow conditions extending through 28 days.