Table 1.
Clinical annotation and PDX characteristics
| PDX model |
Clinical Annotation | PDX characterization | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Histologic subtype |
Source | # of prior lines of chemotherapy |
Prior platinum |
Germline BRCA status |
PAX8 (IHC) |
WT1 (IHC) |
Pan CK (IHC) |
BROCA mutations |
PDX model plasma CA125 |
|
| DF09 | HGSOC | Ascites | 0 | No | Unknown | Positive | Positive | Positive | Not performed | Positive |
| DF14 | HGSOC | Ascites | 5 | Yes | Unknown | Positive | Positive | Positive | Not performed | Positive |
| DF20 | HGSOC | Ascites | 0 | No | Unknown | Positive | Positive | Positive | TP53, PTEN, PPM1D |
Positive |
| DF59 | HGSOC | Ascites | 7 | Yes | BRCA1 5385insC |
Positive | Positive | Positive | Not performed | Positive |
| DF68 | HGSOC | Ascites | 5 | Yes | BRCA1 Q563X |
Positive | Positive | Positive | TP53, BRCA1, PTEN (copy loss) |
Positive |
| DF83 | HGSOC | Ascites | 4 | Yes | Unknown | Positive | Negative | Positive | TP53, CDKN2A (copy loss) |
Positive |
| DF86 | HGSOC | Ascites | 6 | Yes | BRCA1 del exons 21–24 |
Positive | Positive | Positive | TP53, BRCA1, APC |
Positive |
| DF101 | HGSOC | Pleural fluid |
2 | Yes | BRCA1 187delAG |
Positive | Positive | Positive | TP53, BRCA1, NBN, PTEN (copy loss) |
Positive |
| DF106 | HGSOC | Ascites | 1 | Yes | Unknown | Positive | Positive | Positive | TP53, CDKN2A (copy loss) |
Positive |
| DF118 | HGSOC | Ascites | 1 | Yes | Unknown | Positive | Positive | Positive | TP53 | Positive |
| DF149 | HGSOC | Ascites | 0 (previously treated for breast cancer) |
No | Wild type | Positive | Patchy | Positive | TP53 | Positive |
| DF172 | Mixed serous and endometrioid |
Ascites | 2 | Yes | Unknown | Positive | Patchy | Positive | TP53, RET, RAD51C |
Positive |
| DF181 | HGSOC | Ascites | 7 | Yes | Wild type | Negative | Negative | Positive | TP53, BRIP1 | Negative |
| DF216 | Adenoca | Ascites | 2 | Yes | Wild type | Positive | Positive | Positive | TP53 | Positive |