Table 2.
Results of Gene set enrichment analysis.
| Pathway | No. of genes above 75th percentile | p-value | |||
|---|---|---|---|---|---|
| Database | Expected | Observed no. | Nominal | FDR-corrected | |
| MAIN EFFECTS | |||||
| RAS | Panther | 3 | 9 | 8.0 e–4 | 0.02 |
| Vascular Smooth Muscle contraction | KEGG | 26 | 43 | 1.0 e–4 | 0.03 |
| INTERACTION TEST | |||||
| Coenzyme A biosynthesis | Panther | 2 | 6 | 1.6 e–3 | 0.02 |
| 5HT2-type receptor mediated signaling pathway | 2 | 6 | 1.4 e–3 | 0.03 | |
| NDK Dynamin | Biocarta | 4 | 11 | 5.0 e–4 | 0.05 |
| JOINT TEST | |||||
| NRF2-mediated oxidative stress response | Ingenuity | 12 | 25 | 4.7 e–5 | 0.002 |
| ER overload response | GOTERM | 2 | 8 | 1.7 e–5 | 0.004 |