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. 2017 Mar 2;8:116. doi: 10.3389/fphys.2017.00116

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Copyright © 2017 Estrela, Wasinski, Batista, Hiyane, Felizardo, Cunha, de Almeida, Malheiros, Câmara, Barros, Bader and Araujo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protein and mRNA expression of apoptotic factors. Although the Bax/Bcl-2 ratio is similar in the CR+CIS and EX+CIS groups, TNFR2 protein expression was reduced in the CR+CIS group compared to the CIS and EX+CIS groups. (A,B,D,E) mRNA expression and renal protein assay of TNFR1 and TNFR2 by ELISA. (C) Bax/Bcl-2 ratio. (F) Cleaved caspase-3 present in kidney tissues. The section images illustrate the result in panel (F). CIS, cisplatin; EX+CIS, exercise + cisplatin; CR+CIS, caloric restriction + cisplatin. ^* p < 0.05. n = 5–6.