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. 2017 Mar 2;8:67. doi: 10.3389/fneur.2017.00067

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Copyright © 2017 Song, Li, Luo, Zhao, Zhang, Zhang, Jiang, Wang, Chen, Chen, Gong, Zhou and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Measured MTR_asym spectra in the ischemic tissue and the contralateral normal white matter (CNWM) of different stages (corresponding to the APTW_min value). (A) Hyperacute stage. (B) Acute stage. (C) Early subacute stage. (D) Late subacute stage. (E) The combination of MTR_asym spectra in the ischemic tissue of different stages. (F) The combination of MTR_asym spectra in the CNWM of different stages. The chemical exchange saturation transfer effect reduced in the offset range of 2–5 ppm in all stages. MTR_asym(3.5 ppm) showed the largest reduction in the hyperacute stage (A). An increase was shown in the MTR_asym(3.5 ppm) in the ischemic tissue (E).