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. 2017 Feb 28;9(6):300–309. doi: 10.4254/wjh.v9.i6.300

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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Combined hepatocellular-cholangiocarcinoma with stem cell features, typical subtype. A: H and E, 4 × - tumor nests present on the right side with non-neoplastic liver on the left side; B: H and E, 10 × - peripheral small cells with hyperchromatic nuclei with mature appearing hepatocytes in the center; C: CK7, 4 × - scattered expression of CK7 by tumor cells; D: CK19, 4 × - patchy staining of the tumor and highlighting small tumor cells located at the periphery. Tumor was also positive for Hep-Par1 (not shown). H and E: Hematoxylin and eosin.