Figure 4.

Gut homing potential of total CD8+ T_EM. (A) Each value represents the baseline percentages of integrin α₄β₇− and integrin α₄β₇₊ cells in total CD8+ T_EM evaluated by surface staining and flow cytometry for 12 randomly selected TD (squares) and NoTD (circles) participants. *p < 0.05. (B) Ratio of integrin α₄β₇+ to integrin α₄β₇− total CD8+ T_EM cells are shown within four periods of time after challenge. Period d6–d9 corresponds to the time of typhoid diagnosis. Statistical analyses were performed using mixed effects models to account for multiple observations per person. **p < 0.01. (C) Kinetics of expression of integrin α₄β₇+ total CD8+ T_EM after challenge in representative participants from each group.